期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 128, 期 36, 页码 11784-11791出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0627850
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A simple copper-based catalytic system has been developed for the carbon-hydrogen amidation reaction. The copper-homoscorpionate complex Tp(Br3)Cu(NCMe) catalyzes the transfer of the nitrene unit NTs (Ts = p-toluenesulfonyl) and its subsequent insertion into the sp(3) C-H bonds of alkyl aromatic and cyclic ethers or the sp(2) C-H bonds of benzene using Phl=NTs as the nitrene source, affording the corresponding trisubstitued (NRHTs)-H-1 amines in moderate to high yields. The use of the environmentally friendly chloramine-T has also proven effective, with the advantage that sodium chloride is formed as the only byproduct. A tandem, one-pot consecutive nitrene-carbene insertion system has been developed to yield amino acid derivatives.
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