期刊
BEHAVIOURAL BRAIN RESEARCH
卷 172, 期 1, 页码 24-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2006.04.024
关键词
caveolin; knock out mouse model; neurological phenotype; brain histology
资金
- NIGMS NIH HHS [R01 GM 066359] Funding Source: Medline
- NINDS NIH HHS [NS 40738] Funding Source: Medline
Caveolin-1 is the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells. In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear. Mice deficient in cav-1 (CavKO) have been developed to test functional roles for cav-1 in various tissues. However, neurological phenotypes associated with loss of cav-1 in mice have not been evaluated. Here, we report the results of motor and behavioral testing of CavKO mice. We find that mice deficient in cav-1 have reduced brain weight and display a number of motor and behavioral abnormalities. CavKO mice develop neurological phenotypes including clasping, abnormal spinning, muscle weakness, reduced activity, and gait abnormalities. These data suggest that cav-1 is involved in maintaining cortico-stiiato-pallido-thalamo-pontine pathways associated with motor control. (c) 2006 Elsevier B.V. All rights reserved.
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