期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 18, 页码 6202-6212出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.05.073
关键词
camptothecin; anti-cancer agents; topoisomerase 1; cascade radical annulation
资金
- NCI NIH HHS [CA 87061] Funding Source: Medline
Analogs of the anti-tumor agent camptothecin with both closed E-rings (lactone and ether) and open E-rings (reduced acid, hydrazide, and protected Weinreb amide) have been prepared and tested in topoisomerase and cellular assays. The results provide insights into the structural features of the camptothecin E-ring that affect biological activity. (c) 2006 Elsevier Ltd. All rights reserved.
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