期刊
CURRENT BIOLOGY
卷 16, 期 18, 页码 1835-1843出版社
CELL PRESS
DOI: 10.1016/j.cub.2006.07.047
关键词
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资金
- NEI NIH HHS [R01 EY003592, R01 EY015231, EY-03592, 5R01EY015231, R01 EY015231-03] Funding Source: Medline
Specifying synaptic partners and regulating synaptic numbers are at least partly activity-depen dent processes during visual map formation in all systems investigated to date [1-5]. In Drosophila, six photoreceptors that view the same point in visual space have to be sorted into synaptic modules called cartridges in order to form a visuotopically correct map (6, 7]. Synapse numbers per photoreceptor terminal and cartridge are both precisely regulated [8-10]. However, it is unknown whether an activity-dependent mechanism or a genetically encoded developmental program regulates synapse numbers. We performed a large-scale quantitative ultrastructural analysis of photoreceptor synapses in mutants affecting the generation of electrical potentials (norpA, trp;trpl), neurotransmitter release (hdc, syt), vesicle endocytosis (synj), the trafficking of specific guidance molecules during photoreceptor targeting (sec15), a specific guidance receptor required for visual map formation (Dlar, and 57 other novel synaptic mutants affecting 43 genes. Remarkably, in all these mutants, individual photoreceptors form the correct number of synapses per presynaptic terminal independently of cartridge composition. Hence, our data show that each photoreceptor
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