期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 38, 页码 14188-14193出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0605985103
关键词
transcription; regulation; high-mobility group A protein; HMGA1a
资金
- NCI NIH HHS [R01 CA070723, P01 CA022443] Funding Source: Medline
- NIAID NIH HHS [R37 AI-20201] Funding Source: Medline
EBV is a paradigm for human tumor viruses because, although it infects most people benignly, it also can cause a variety of cancers. Both in vivo and in vitro, EBV infects B lymphocytes in G(0), induces them to become blasts, and can maintain their proliferation in cell culture or in vivo as tumors. How EBV succeeds in these contrasting cellular environments in expressing its genes that control the host has not been explained. We have genetically dissected the EBV nuclear antigen 1 (EBNA1) gene that is required for replication of the viral genome, to elucidate its possible role in the transcription of viral genes. Strikingly, EBNA1 is essential to drive transcription of EBV's transforming genes after infection of primary B lymphocytes.
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