期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1128, 期 1-2, 页码 164-170出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2006.06.061
关键词
HPLC-ICPMS; arsenic; thio-arsenicals; speciation analysis; reversed-phase
A new group of arsenic species, thio-arsenicals, have recently been reported in several natural samples such as molluscs, algae, and urine. These compounds are the sulfur analogues of oxo-arsenicals, a large group of naturally-occurring compounds, whereby the arsinoyl (As=O) group is substituted by an arsinothioyl group (As=S). The most common separation technique for oxo-arsenicals is anion-exchange HPLC with polymer-based columns, but under these conditions the thio-arsenicals show strong retention, resulting in unacceptably long analysis times and broad peaks. We report the development of a reversed-phase HPLC method, with ICPMS detection, which allows separation of the known thio-arsenicals within 15 min with significantly improved peak shapes. The detection limit is about 0.6 mu g As/L based on 10 mu L injection volume. Further, we have applied the method to the identification and quantification of thio-arsenic species in two standard reference materials, BCR 710 oyster tissue and NIES 18 human urine. (c) 2006 Elsevier B.V. All rights reserved.
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