Effects of Adapalene-Benzoyl Peroxide Combination Gel in Treatment or Maintenance Therapy of Moderate or Severe Acne Vulgaris: A Meta-Analysis

Background: An antibiotic-free, fixed-dose combination gel with adapalene (A) 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for treatment of acne vulgaris. Objective: To compare the clinical outcomes of A-BP combination gel with vehicle gel for treatment or maintenance therapy of patients with acne vulgaris. Methods: An electronic search of the database PubMed (1966 to September 2012), Embase (1984 to September 2012), and Cochrane Controlled Trials Register (CENTRAL; 3rd Quarter, 2012) was undertaken to identify relevant studies. Main clinical outcomes were success rate, treatment-related adverse events (AEs), AEs leading to discontinuation, satisfaction with the effectiveness, and overall satisfaction. Results: Six studies were finally included in this meta-analysis. The A-BPO group yielded better clinical outcomes regarding the success rate (p < 0.00001), satisfaction with the effectiveness of treatment (p = 0.005), and overall satisfaction (p = 0.005) compared to the vehicle group. The incidence of treatment-related AEs in the A-BP group was comparable with that of vehicle group (p = 0.09), while the A-BP group was associated with a slightly increase in the incidence of AEs leading to discontinuation when compared with the vehicle group (p = 0.02). Conclusion: A-BP combination gel yields better clinical outcomes including success rate, satisfaction with the effectiveness, and overall satisfaction compared to vehicle gel, despite an increased incidence of AEs leading to discontinuation. The A-BP combination agent most likely contributes to the treatment of moderate acne vulgaris rather than severe acne vulgaris, but it may be useful in maintenance therapy of patients with severe acne vulgaris.