期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 30, 期 7, 页码 1231-1234出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2006.03.016
关键词
amphetamine; animal model; bipolar disorder; glial fibrillary acidic protein (GFAP); mania
Introduction: Psychostimulants such as amphetamine (AMPH) induce manic-like symptoms in humans and studies have suggested that bipolar disorder (BD) may be associated to dopamine dysfunction. Glial fibrillary acidic protein (GFAP) up-regulation is considered a marker of astrogliosis, and it has been associated to behavioral sensitization. Purpose: We aimed to investigate the behavioral effects of acute and chronic AMPH on rat locomotion and assess GFAP levels in rat cortex and hippocampus. Methods: Rats were administered either acute (single dose) or chronic (seven days) D-amphetamine IP injection. Locomotion was assessed with an open-field test and GFAP immunoquantity was measured using ELISA. Results: Chronic, but not acute, administration of AMPH increased GFAP levels in rat hippocampus. No differences were observed in rat cortex. Conclusions: Repeated exposure to AMPH leads to an astroglial response in the hippocampus of rats. (c) 2006 Elsevier Inc. All rights reserved.
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