期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 21, 期 10, 页码 1565-1570出版社
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.060715
关键词
osteoporosis; treatment resistance; fracture risk; treatment compliance; calcium and vitamin D intake
None of the available osteoporosis therapies have been shown to completely abolish the risk of fractures. In clinical practice, the outcome may be even poorer. In 880 patients prescribed with antiresorptives (alendronate, risedronate, and raloxifene) for > 1 year, a fragility fracture was recorded in 8.9 %/year of them. This incidence is considerably higher than that observed in randomized clinical trials, and it was significantly related to poor compliance and lack of supplementation with calcium and vitamin D.
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