期刊
PEPTIDES
卷 27, 期 10, 页码 2385-2404出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2006.04.024
关键词
neurotensin; dopamine; schizophrenia; antipsychotic drugs; drugs of abuse; Parkinson's disease
资金
- NIMH NIH HHS [MH-39415] Funding Source: Medline
Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction. (c) 2006 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据