期刊
SEMINARS IN CANCER BIOLOGY
卷 16, 期 5, 页码 383-392出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2006.07.001
关键词
HLA class 1; HLA-G; ICAM-1; MIC; NKG2D; ULBP
类别
资金
- NCI NIH HHS [R01 CA67108, R01 CA113861, R01 CA110249] Funding Source: Medline
Malignant transformation of cells is frequently associated with HLA class I antigen downregulation or loss. This abnormality provides malignant cells with a mechanism to escape control by HLA class I antigen-restricted, tumor antigen-specific cytotoxic T lymphocytes. Surprisingly, HLA class I antigen downregulation or loss by tumor cells is not associated with control of tumor growth by natural killer (NK) cells, as it would be predicted by the missing-self hypothesis. Here, we discuss the role of NK cell activating ligand abnormalities as well as HLA class I molecule and ICAM-1 shedding in the lack of control of tumor growth by NK cells with emphasis on their molecular mechanisms. In addition, we discuss the impact of these abnormalities on cancer immune surveillance. (c) 2006 Elsevier Ltd. All rights reserved.
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