期刊
ANNALS OF DERMATOLOGY
卷 23, 期 4, 页码 468-473出版社
KOREAN DERMATOLOGICAL ASSOC
DOI: 10.5021/ad.2011.23.4.468
关键词
Atopic dermatitis; IL-31 mRNA; Itching; SCORAD; Serum IL-31
类别
资金
- Ministry of Health and Welfare, Republic of Korea [01-PJ3-PG6-01GN12-0001]
- Samsung Biomedical Research Institute [C-A6-216-3]
Background: Severe pruritus is the primary symptom in atopic dermatitis (AD). Recently, the novel cytokine IL-31 has been implicated in the itching associated with AD. Objective: We performed this study to determine whether IL-31 serum levels are elevated in AD patients and to better characterize the relationship between serum IL-31 level and other established laboratory parameters. Methods: We recruited 55 AD patients, 34 with allergic type AD and 21 with non-allergic type AD, and 38 healthy, non-atopic controls. We checked the laboratory values, severity score, and serum IL-31 levels in all patients and controls, and IL-31 mRNA levels in lesion skin were measured in 13 subjects with AD and in four controls. Results: AD patients displayed significantly higher levels of serum IL-31 that were associated with serum IgE, disease severity, and subjective itch intensity. In AD patients, IL-31 mRNA levels from the lesional skin samples also correlated with serum IL-31 level. Conclusion: IL-31 is likely one of the many mediators inducing inflammation and pruritus in AD. Although our limited sample size prevents us from making any definitive conclusions, our data demonstrate a strong correlation between IL-31 mRNA level and serum IL-31 protein level, which has never been reported before. Moreover, we found correlations between serum IL-31 level and serum IgE, eosinophil cationic protein, disease severity, and subject itch intensity in certain degrees in AD patients. (Ann Dermatol 23(4) 468 similar to 473, 2011)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据