期刊
CURRENT OPINION IN ANESTHESIOLOGY
卷 19, 期 5, 页码 473-480出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.aco.0000245270.90377.00
关键词
cerebral blood flow; cerebral metabolism; imaging; ischaemia; perfusion
资金
- Medical Research Council
- Technology Foresight Award from the UK Government
- Royal College of Anaesthetists/British Journal of Anaesthesia project grant
- Academy of Medical Sciences/Health Foundation
- Addenbrooke's Charities
- Wellcome Foundation
- Beverley and Raymond Sackler studentship award
Purpose of review To review the techniques for imaging cerebral blood flow and metabolism following injury to the brain. Recent findings Xenon enhanced computerized tomography (Xenon CT), CT perfusion and single photon emission CT provide measurements of cerebral perfusion, while positron emission tomography (PET), and magnetic resonance imaging and spectroscopy (MRI and MRS) are able to assess both perfusion and cerebral metabolism. Xenon CT and CT perfusion are readily available and have proved useful in a variety of causes of brain injury. PET is an extremely useful research tool for defining cerebral physiology, but is limited in its availability. Despite the continuing development of MRI and MRS imaging, the scanning environment remains hostile for critically ill patients, and further research is required before the techniques become generally available. Summary Imaging of cerebral blood flow and metabolism has been shown to be useful following a variety of causes of brain injury, as it can help to define the cause and extent of injury, identify appropriate treatments and predict outcome. Imaging based on CT techniques (Xenon CT and CT perfusion) can be implemented easily in most hospital centres, and are able to provide quantitative perfusion data in addition to structural images.
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