期刊
MOLECULAR MICROBIOLOGY
卷 62, 期 2, 页码 356-366出版社
WILEY
DOI: 10.1111/j.1365-2958.2006.05375.x
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资金
- Medical Research Council [G0400926] Funding Source: researchfish
- MRC [G0400926] Funding Source: UKRI
- Medical Research Council [G0400926] Funding Source: Medline
- Wellcome Trust [079819] Funding Source: Medline
Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.
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