期刊
TRENDS IN NEUROSCIENCES
卷 29, 期 10, 页码 587-599出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2006.08.005
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资金
- NIA NIH HHS [R37 AG 08796, AG 17139] Funding Source: Medline
- NIMH NIH HHS [MH 67251, MH 47340] Funding Source: Medline
In vitro experiments indicate that intrinsic neuronal excitability, as evidenced by changes in the post-burst afterhyperpolarization (AHP) and spike-frequency accommodation, is altered during learning and normal aging in the brain. Here we review these studies, highlighting two consistent findings: (i) that AHP and accommodation are reduced in pyramidal neurons from animals that have learned a task; and (ii) that AHP and accommodation are enhanced in pyramidal neurons from aging subjects, a cellular change that might contribute to age-related learning impairments. Findings from in vivo single-neuron recording studies complement the in vitro data. From these consistently reproduced findings, we propose that the intrinsic AHP level might determine the degree of synaptic plasticity and learning. Furthermore, it seems that reductions in the AHP must occur before learning if young and aging subjects are to learn a task successfully.
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