期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 21, 期 10, 页码 1581-1590出版社
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.060701
关键词
long-term risedronate treatment; postmenopausal osteoporosis; Fourier transform infrared imaging; mineral maturity/crystallinity; collagen cross-links
Long-term effects of risedronate on bone mineral maturity/crystallinity and collagen cross-link ratio in triple iliac crest biopsies of osteoporotic women were evaluated. In this double-blinded study, 3- and 5-year treatment with risedronate arrested the tissue aging encountered in untreated osteoporosis and in osteoporosis treated with other antiresorptives. This effect may be contributing to risedronate's antifracture efficacy.
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