期刊
ENGINEERING IN LIFE SCIENCES
卷 6, 期 5, 页码 488-491出版社
WILEY
DOI: 10.1002/elsc.200620152
关键词
cell cultivation; fungi; modeling; proteins
Optimization and modeling of cultivation processes for the production of heterologous and homologous proteins requires a comprehensive characterization of product formation. Methods have been developed for the experimental investigation of mass transport, substrate turnover and product formation in biopellets of the fungus Aspergillus niger for the production of glucoamylase (GAM). GAM production in A. niger was chosen as a model system, its advantage being its potential for complex, posttranslational protein modifications.
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