期刊
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
卷 12, 期 4, 页码 465-472出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1076029606293433
关键词
heparin osteoporosis; osteoblast; osteocalcin; Cbfa-1
Heparin may cause adverse effects on bone formation following long-term application. The exact pathomechanism is unclear, but in vitro data suggest an impaired osteoblast function. The transcription axis of Cbfa-1 (Runx-2) and osteocalcin is crucial in maintaining an equilibrium of bone formation and resorption in vivo. We used a human osteoblast cell culture model to further investigate the effect of heparin (low-molecular-weight heparin, dalteparin) on the expression of these two regulators of osteoblast differentiation. At high doses, dalteparin caused a significant inhibition of both osteocalcin and Cbfa-1 expression in vitro. Our data support the hypothesis of a direct inhibition of osteoblast function underlying heparin osteoporosis.
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