期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 7, 期 10, 页码 751-761出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2022
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Sliding clamps are ring-shaped proteins that tether DNA polymerases to DNA, which enables the rapid and processive synthesis of both leading and lagging strands at the replication fork. The clamp-loading machinery must repeatedly load sliding-clamp factors onto primed sites at the replication fork. Recent structural and biochemical analyses provide unique insights into how these clamp-loading ATPase machines function to load clamps onto the DNA. Moreover, these studies highlight the evolutionary conservation of the clamp-loading process in the three domains of life.
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