期刊
NATURE GENETICS
卷 38, 期 10, 页码 1159-1165出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1886
关键词
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资金
- NCRR NIH HHS [2 R01 RR07801, R01 RR007801] Funding Source: Medline
Here we present a quantitative and predictive model of the transcriptional readout of the proximal 1.7 kb of the control region of the Drosophila melanogaster gene even skipped ( eve). The model is based on the positions and sequence of individual binding sites on the DNA and quantitative, time-resolved expression data at cellular resolution. These data demonstrated new expression features, first reported here. The model correctly predicts the expression patterns of mutations in trans, as well as point mutations, insertions and deletions in cis. It also shows that the nonclassical expression of stripe 7 driven by this fragment is activated by the protein Caudal (Cad), and repressed by the proteins Tailless (TII) and Giant (Gt).
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