Oocyte cryopreservation

The incorporation of oocyte cryopreservation into the clinical practice of assisted reproduction long has been a goal of many practitioners. Oocyte cryopreservation complements assisted reproduction by extending its application to fertile women. It may be used to avoid long-term embryo cryopreservation, to rescue cycles complicated by ovarian hyperstimulation syndrome or failure to obtain sperm, and to avoid synchronization issues in oocyte-donation cycles. Fertile women may take advantage of this technology to electively delay childbearing or as a strategy for fertility preservation when faced with a new diagnosis of cancer and sterilizing therapies such as chemotherapy and radiation or extirpative surgery. Recent advances in assisted reproduction and embryology, including improved culture media, fertilization with intracytoplasmic sperm injection (ICSI), and optimization of cryoprotectants, have made oocyte cryopreservation a viable reality. This review focuses on the etiology of oocyte cryopreservation, history of oocyte cryopreservation, recent advances, and clinical outcomes.