4.6 Article

Bone sialoprotein enhances migration of bone marrow stromal cells through matrices by bridging MMP-2 to αvβ3-integrin

期刊

JOURNAL OF BONE AND MINERAL RESEARCH
卷 21, 期 10, 页码 1627-1636

出版社

WILEY
DOI: 10.1359/JBMR.060710

关键词

bone marrow stromal cells; bone sialoprotein; small integrin-binding ligand; N-linked glycoprotein; alpha(v)beta(3) integrin; matrix metalloproteinase 2

资金

  1. Intramural NIH HHS Funding Source: Medline

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BMSCs migrate through matrix barriers and differentiate into osteoblasts. BSP enhances osteogenic cell migration through basement membrane and collagen matrices in vitro by localizing MMP-2 on the cell surface through alpha(v)beta(3)-integrin.

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