期刊
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
卷 27, 期 5, 页码 521-533出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2006-954609
关键词
lung transplantation; acute rejection; immunosuppression; bronchiolitis obliterans
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischemia-reperfusion injury and infections have contributed to increase the 1 year patient survival after lung transplantation to 70 to 80%. However, the incidence of acute rejection remains higher than after other types of solid organ transplantation, and long-term survival is threatened by bronchiolitis obliterans, which is thought to be a form of chronic allograft rejection. This article reviews major aspects of clinical presentation, risk factors, diagnosis, and management of acute and chronic rejection after lung transplantation.
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