4.6 Article

Racial and ethnic disparities in idiopathic pulmonary fibrosis: A UNOS/OPTN database analysis

期刊

AMERICAN JOURNAL OF TRANSPLANTATION
卷 6, 期 10, 页码 2436-2442

出版社

WILEY
DOI: 10.1111/j.1600-6143.2006.01480.x

关键词

cohort; diffuse parenchymal lung disease; forced vital capacity; interstitial lung disease; lung transplantation

资金

  1. NHLBI NIH HHS [HL072739, K23 HL067771, HL67771, T32 HL072739, L30 HL086095] Funding Source: Medline
  2. PHS HHS [231-00-0115] Funding Source: Medline

向作者/读者索取更多资源

We previously reported poorer survival among non-Hispanic blacks and Hispanics with idiopathic pulmonary fibrosis (IPF) compared to non-Hispanic whites at our center. In the current study, we hypothesized that these disparities would exist in a nationwide cohort of wait-listed patients with IPF. We performed a retrospective cohort study of 2635 patients with IPF listed for lung transplantation between 1995 and 2003 at 94 transplant centers in the United States. The age-adjusted mortality rate was higher among non-Hispanic blacks [hazard ratio (HR) = 1.24, 95% confidence interval (CI) 1.06-1.45, p = 0.009] and Hispanics (HR = 1.29, 95% CI 1.06-1.56, p = 0.01) compared to non-Hispanic whites. These findings persisted after adjustment for transplantation, medical comorbidities and socioeconomic status. Worse lung function at the time of listing appeared to explain some of these differences (HR for non-Hispanic blacks after adjustment for forced vital capacity percent predicted = 1.16, 95% CI 0.98-1.36, p = 0.09; HR for Hispanics = 1.21, 95% CI 0.99-1.48, p = 0.056). In summary, black and Hispanic patients with IPF have worse survival than whites after listing for lung transplant.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据