期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 42, 期 7, 页码 1391-1405出版社
SPRINGER
DOI: 10.1007/s10439-013-0966-4
关键词
Skeletal muscle; Cardiac muscle; Bioreactor; Tissue engineering; Biomimetic
资金
- NIH-NIAMS [AR055226, AR065873]
- NIH-NHLBI [HL104326]
- NIH Common Fund for the Microphysiological Systems Initiative Grant [UH2TR000505]
The field of tissue engineering involves design of high-fidelity tissue substitutes for predictive experimental assays in vitro and cell-based regenerative therapies in vivo. Design of striated muscle tissues, such as cardiac and skeletal muscle, has been particularly challenging due to a high metabolic demand and complex cellular organization and electromechanical function of the native tissues. Successful engineering of highly functional striated muscles may thus require creation of biomimetic culture conditions involving medium perfusion, electrical and mechanical stimulation. When optimized, these external cues are expected to synergistically and dynamically activate important intracellular signaling pathways leading to accelerated muscle growth and development. This review will discuss the use of different types of tissue culture bioreactors aimed at providing conditions for enhanced structural and functional maturation of engineered striated muscles.
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