期刊
JOURNAL OF IMMUNOLOGY
卷 177, 期 7, 页码 4257-4261出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.7.4257
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资金
- NCI NIH HHS [R01 CA109339, R01 CA109339-02, CA 109339] Funding Source: Medline
- NIAID NIH HHS [R01 AI057441, R01 AI057441-02, R56 AI057441, AI 057441] Funding Source: Medline
IL-2 is expressed predominantly by activated T cells, and regulates T cell function by activating, via its receptor, the latent transcription factor STAT5. This signaling can occur in either a paracrine (between cells) or an autocrine (same cell) manner, although the kinetics by which these two Signaling modes operate during in vivo T cell responses are unknown. In the current study, IL-2 expression and signaling in a clonotypic population of antiviral CD4(+) T cells was analyzed by flow cytometry during the initial 24 h of priming. IL-2 expression and STAT5 activation peaked in parallel, but surprisingly, were almost completely mutually exclusive. Thus, only paracrine IL-2 signaling could be observed. As an additional indication of the efficiency of paracrine IL-2 signaling, polyclonal CD4(+)CD25(+)Foxp3(+) regulatory T cells displayed detectable STAT5 activation under steady-state conditions, which was strongly enhanced by neighboring IL-2-expressing antiviral CD4 cells.
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