期刊
BIOTECHNOLOGY LETTERS
卷 28, 期 19, 页码 1559-1565出版社
SPRINGER
DOI: 10.1007/s10529-006-9130-7
关键词
dynamic kinetic resolution; ionic liquids; supercritical fluids; multiphase biocatalysis; lipases
Continuous dynamic kinetic resolution processes in different ionic liquid/supercritical carbon dioxide biphasic systems were carried out by simultaneously using both immobilized Candida antarctica lipase B (Novozym 435) and silica modified with benzenosulfonic acid (SCX) catalysts at 40 degrees C and 10 MPa. SCX was seen to act as an efficient heterogeneous chemical catalyst for the racemization of (S)-1-phenylethanol in different ionic liquid media ([emim][NTf2], [btma][NTf2] and [bmim][PF6]). Coating both chemical and enzymatic catalysts with ILs greatly improved the efficiency of the process, providing a good yield (76%) of (R)-1-phenylethyl propionate product with excellent enantioselectivity (ee = 91-98%) in continuous operation.
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