期刊
JOURNAL OF NEUROTRAUMA
卷 23, 期 10, 页码 1450-1467出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2006.23.1450
关键词
catecholamines; episodic memory; functional MRI; traumatic brain injury; working memory
资金
- NICHD NIH HHS [R01 HD048176] Funding Source: Medline
- NINDS NIH HHS [R01 NS40472] Funding Source: Medline
Cognitive complaints are a frequent source of distress and disability after mild and moderate traumatic brain injury (TBI). While there are deficits in several cognitive domains, many aspects of these complaints and deficits suggest that problems in working memory (WM) play an important role. Functional imaging studies in healthy individuals have outlined the neural substrate of WM and have shown that regions important in WM circuitry overlap with regions commonly vulnerable to damage in TBI. Use of functional MRI (fMRI) in individuals with mild and moderate TBI suggests that they can have problems in the activation and allocation of WM, and several lines of evidence suggest that subtle alterations in central catecholaminergic sensitivity may underlie these problems. We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI.
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