期刊
DEVELOPMENT
卷 133, 期 19, 页码 3767-3775出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.02552
关键词
epiblast; primitive streak; paraxial mesoderm; somites; BMP; FGF; mouse
资金
- Intramural NIH HHS Funding Source: Medline
- NICHD NIH HHS [P01HD39948] Funding Source: Medline
- NIDCR NIH HHS [R01DE013674] Funding Source: Medline
Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MORE embryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据