期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 19, 页码 6548-6554出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.06.012
关键词
amphidinol; structure elucidation; antifungal; hemolysis; membrane permeabilization; structure-activity relationship
Two new homologues of amphidinols (AM14 and AM15) were isolated from the cultured dinoflagellate Amphidinium klebsii. The structures were elucidated on the basis of 2D NMR and collision-induced dissociation MS/MS and turned out to be closely related homologues of AM7. Their weak membrane-disrupting activity indicates that the hydrophobic polyene chain is essential for the potent biological activities. Structure-activity relationship for the polyhydroxyl part was then examined with use of AM homologues possessing various chain lengths, indicating that the pore size of the channel/lesion formed by AMs was not greatly affected by the length of the polyhydroxyl chain. (c) 2006 Elsevier Ltd. All rights reserved.
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