期刊
BIOESSAYS
卷 28, 期 10, 页码 983-993出版社
JOHN WILEY & SONS INC
DOI: 10.1002/bies.20477
关键词
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资金
- NIGMS NIH HHS [R01 GM052932-08, R01 GM052932] Funding Source: Medline
The Rho GTPases-Rho, Rac and Cdc42-act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state, to regulate the actin cytoskeleton. It has recently become apparent that the Rho GTPases can be activated in subcellular zones that appear semi-stable, yet are dynamically maintained. These Rho GTPase activity zones are associated with a variety of fundamental biological processes including symmetric and asymmetric cytokinesis and cellular wound repair. Here we review the basic features of Rho GTPase activity zones, suggest that these zones represent a fundamental signaling mechanism, and discuss the implications of zone properties from the perspective of both their function and how they are likely to be controlled.
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