期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 16, 期 7, 页码 457-465出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2005.09.005
关键词
oxidative stress; atherosclerosis; lipoprotein; hypertriglyceridaemia
Objectives: To analyse the HDL associated anti-oxidant enzyme paraoxonase-1, during postprandial hyperlipaemia. Methods and results: Type 2 diabetic patients (n = 72), glucose intolerant patients (n = 10) and controls (n = 38) consumed a high fat:high carbohydrate meal. Blood samples were collected up to 4 h and analysed for lipids and paraoxonase-1. In vitro studies examined HDL function with respect to the enzyme. There were significant postprandial increases in serum triglycerides. Paraoxonase-1 activity decreased significantly throughout the postprandial phase. Concentrations of the enzyme initially decreased significantly, but returned to fasting concentrations at 4 h. Specific activities were significantly lower at 4 h, compared to fasting. The decrease in specific activity was linked to the dynamic phase of postprandial. lipoprotein metabolism. Apo Al limited loss of paraoxonase-1. HDL isolated after being subjected to post-prandial conditions in vitro had reduced capacity to associate with and stabilise PON1. Conclusions: Postprandial hyperlipaemia was associated with changes to serum paraoxonase-1, consistent with a reduced anti-oxidant potential of HDL. No differences were observed between diabetic and non-diabetic patients, suggesting that the effect was linked to postprandial hyperlipaemia. Modifications to paraoxonase-1 could contribute to increased risk of vascular disease associated with postprandial lipaemia, particularly in diabetic patients, who are already deficient in serum paraoxonase-1. (C)2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据