期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1763, 期 10, 页码 991-999出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2006.08.008
关键词
Thy-1; GPI anchor; cell signaling; integrins; tyrosine kinases; lipid rafts
资金
- NCRR NIH HHS [C06 RR015490, C06 RR 15490] Funding Source: Medline
- NHLBI NIH HHS [R01 HL065348, HL065348] Funding Source: Medline
- NINDS NIH HHS [NS49674, F30 NS049674] Funding Source: Medline
Thy-1 is a 25-37 kDa glycosylphosphatidylinositol (GPI)-anchored protein involved in T cell activation, neurite outgrowth, apoptosis, tumor suppression, wound heating, and fibrosis. To mediate these diverse effects, Thy-1 participates in multiple signaling cascades. In this review, we discuss Thy-1 signaling primarily in non-immunologic cell types, including neurons, mesangial cells, ovarian cancer cells, nasopharyngeal carcinoma cells, endothelial cells, and fibroblasts. We review the current literature regarding Thy-1 signaling via integrins, protein tyrosine kinases, and cytokines and growth factors; and the roles of these signaling pathways in cellular adhesion, apoptosis, cell proliferation, and cell adhesion and migration. We also discuss the role of Thy-1 localization to lipid rafts, and of the GPI anchor in Thy-1 signaling. Ongoing research on the mechanisms of Thy-1 signaling will add to our understanding of the diverse physiologic and pathologic processes in which Thy-1 plays a role. (c) 2006 Elsevier B.V. All rights reserved.
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