期刊
BLOOD
卷 108, 期 7, 页码 2265-2274出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-02-004762
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Thymosin alpha 1 (T alpha 1), a naturally occurring thymic peptide, primes dendritic cells (DCs) for antifungal T-helper type 1 resistance through Toll-like receptor 9 (TLR9) signaling. As TLR9 signaling also activates the immuno-suppressive pathway of tryptophan catabolism via indoleamine 2,3-dioxygenase (IDO), we examined T alpha 1 for possible induction of DC-dependent regulatory effects. T alpha 1 affected T-helper cell priming and tolerance induction by human and murine DCs and induced IDO expression and function in the latter cells. IDO activation by T alpha 1 required TLR9 and type 1 interferon receptor signaling and resulted in interleukin-10 production and generation of regulatory T cells. In transfer experiments, functionally distinct subsets of differentiated DCs were required for priming and tolerance to a fungal pathogen or alloantigens. In contrast, T alpha 1-primed DCs fulfilled multiple requirements, including the induction of T-helper type 1 immunity within a regulatory environment. Thus, instructive immunotherapy with T alpha 1 targeting IDO-competent DCs could allow for a balanced control of inflammation and tolerance.
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