期刊
ANNALS OF APPLIED PROBABILITY
卷 23, 期 1, 页码 230-250出版社
INST MATHEMATICAL STATISTICS
DOI: 10.1214/11-AAP824
关键词
Exponentially growing population; site frequency spectrum; multitype branching process; cancer model
资金
- NSF [DMS-10-05470]
- NIH [R01-GM096190-02]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1057675] Funding Source: National Science Foundation
In order to analyze data from cancer genome sequencing projects, we need to be able to distinguish causative, or driver, mutations from passenger mutations that have no selective effect. Toward this end, we prove results concerning the frequency of neutural mutations in exponentially growing multitype branching processes that have been widely used in cancer modeling. Our results yield a simple new population genetics result for the site frequency spectrum of a sample from an exponentially growing population.
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