期刊
IMMUNOLOGY
卷 119, 期 2, 页码 203-211出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2567.2006.02425.x
关键词
human T lymphocytes; chimeric receptors; FOXP3; splice variants; inhibition of T-cell activation
类别
FOXP3 has been identified as a key regulator of immune homeostasis. Mutations within the FOXP3 gene result in dysregulated CD4(+) T-cell function and elevated cytokine production, leading to lymphoproliferative disease. FOXP3 expression in CD4(+) T cells is primarily detected with the CD4(+) CD25(+) regulatory T-cell population. In humans the protein is detected as a doublet following immunoblot analysis. The lower band of the doublet has been identified as a splice isoform lacking a region corresponding to exon 2. The aim of this study was to investigate whether the splice variant form lacking exon 2 and a new novel splice variant lacking both exons 2 and 7, were functional inhibitors of CD4(+) T-cell activation. The data generated showed that full-length FOXP3 and both splice variant forms of the protein were functional repressors of CD4(+) T-cell activation.
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