期刊
GENOMICS
卷 88, 期 4, 页码 407-414出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2006.04.004
关键词
CEPH; HapMap; haplotype; tagSNP
资金
- NHLBI NIH HHS [R01 HL074168, R01 HL074168-04, HL74168] Funding Source: Medline
- NIDDK NIH HHS [DK065598, R01 DK065598] Funding Source: Medline
The International HapMap Consortium has determined the linkage disequilibrium (LD) patterns of four major human populations. The aim of our investigation was to compare the LD patterns of the HapMap CEPH (Centre d'Etude du Polymorphisme Humain) samples with a family-based cohort of similar ancestry to determine its usefulness as a reference population for disease association studies. We examined four genomic regions on chromosomes 7q, 12p, and 14q totaling 14.3 Mb, initially identified in our linkage study of obesity and the metabolic syndrome. Near identical patterns of LD were detected in both populations. Furthermore, tagSNPs selected based on the HapMap CEPH cohort data capture over 98% of the variants at an r(2) > 0.8 in the disease cohort. This confirms the usefulness of the CEPH cohort of the HapMap as a reference sample for further investigations into the genomic variation of populations of Northern European descent. (c) 2006 Elsevier Inc. All rights reserved.
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