期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 116, 期 10, 页码 2571-2579出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI29812
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资金
- NIDDK NIH HHS [DK58538, R01 DK065055, DK65055, DK64643, R01 DK058538, K08 DK064643] Funding Source: Medline
The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.
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