期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 21, 期 10, 页码 759-765出版社
SPRINGER
DOI: 10.1007/s10654-006-9065-2
关键词
blood pressure; cohort; famine; Netherlands; nutrition
资金
- NHLBI NIH HHS [R01 HL067914] Funding Source: Medline
We compared blood pressure of individuals (mean age 59 y) born in western Holland between January 1945 and March 1946 (mothers exposed to the Dutch Famine before or during gestation; n = 359) to blood pressure of unexposed individuals born before or conceived after the famine (n = 299) or same-sex siblings of subjects in series 1 or 2 (n = 313). Mean (SD) systolic and diastolic blood pressure were 140.3 (20.3) and 85.8 (11.0) mmHg, respectively; prevalence of hypertension (prior diagnosis of hypertension or with measured systolic/diastolic blood pressure above 140/90 mmHg) was 61.8%. Birth weight was inversely related to systolic (-4.14 mmHg per kg; 95% confidence interval (CI) -7.24, -1.03; p < 0.01) and diastolic (-2.09 mmHg per kg; 95% CI -3.77, -0.41; p < 0.05) blood pressure and to the prevalence of hypertension (odds ratio 0.67 per kg, 95% CI: 0.49, 0.93) (all age- and sex-adjusted). Any famine exposure of at least 10 weeks duration was associated with elevated systolic (2.77 mmHg; 95% CI 0.25, 5.30; p < 0.05) and diastolic (1.27 mmHg; 95% CI -0.13, 2.66; p = 0.08) blood pressure and with hypertension prevalence (odds ratio 1.44; 95% CI 1.04, 2.00; p < 0.05) in age- and sex-adjusted models. Exposure to famine during gestation may predispose to the development of hypertension in middle age.
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