期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 19, 页码 5097-5101出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.07.029
关键词
filifolinol; complement inhibition; 3H-spiro[benzofuran-2,1 '-cyclohexanes]; analogs of K76
Six 3H-spiro[benzofuran-2,1 '-cyclohexane] derivatives were synthesized from naturally occurring filifolinol, and their classical complement pathway inhibitory activity was determined. IC50 values of the most potent compounds were comparable to the activity of the natural complement inhibitor K76-COOH and some synthetic tricyclic analogs of it. (c) 2006 Elsevier Ltd. All rights reserved.
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