期刊
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
卷 195, 期 2, 页码 189-198出版社
ELSEVIER GMBH
DOI: 10.1016/j.aanat.2012.08.005
关键词
Feather cells; Cornification; Keratins; Keratin associated beta-proteins; Ultrastructural localization
资金
- RFO Grant from University of Bologna
The maturation of the corneous material of feathers is a special case of cornification in vertebrate epidermis and is believed to occur mainly by the accumulation of small proteins of about 100 amino acids and a central beta-pleated sheet region known as feather keratins. The present immunocytochemical study carried out using double-labeling immunogold shows that a small amount of alpha-keratins of intermediate filament type form the early keratin clumps in barb and barbule cells. These initial nuclei of formation of corneous material are rapidly coated by the deposition of large amounts of small feather keratin-associated beta-proteins (feather keratins). The latter proteins turn the keratin bundles of barb and barbule cells into a compact and apparently amorphous mass of corneous material where no sign of intermediate filaments are seen. Feather beta-proteins however form an irregular filamentous network of 2-3 nm thick electron-pale filaments and produce the characteristic feather X-ray pattern due to their prevalent amount over any other protein present in feather cells. The modality of cornification in feathers is discussed in relation to the process of formation of corneous material in the skin of vertebrates in general that occurs by the association of intermediate filament proteins and keratin-associated proteins. (c) 2012 Elsevier GmbH. All rights reserved.
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