期刊
PSYCHIATRY AND CLINICAL NEUROSCIENCES
卷 60, 期 5, 页码 633-635出版社
WILEY
DOI: 10.1111/j.1440-1819.2006.01570.x
关键词
case-control study; schizophrenia; X-box binding protein 1 (XBP1)
The functional promoter polymorphism -116C/G of the X-box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case-control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 -116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.
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