期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 40, 期 7, 页码 622-626出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2005.05.006
关键词
phenotype; genetics; schizophrenia; epidemiology; bias; trios
类别
资金
- Medical Research Council [G9309834, G9810900] Funding Source: Medline
- MRC [G9810900, G9309834] Funding Source: UKRI
- Medical Research Council [G9309834, G9810900] Funding Source: researchfish
Background: Phenotypic differences between parent-offspring trios and non-trios have been reported for various psychiatric disorders, and it has been suggested that this may make comparisons of case-control and family-based results for gene-disease association studies inappropriate. Aims: To compare phenotypes between trios and non-trios with schizophrenia, and explore possible reasons for differences observed. Method: Phenotypes were compared between trios (n = 75) and non-trios (n = 424) collected as part of a case-control study. Conclusions: Confounding, genetic heterogeneity or selection bias could result in differences in case-control and family-based results. However as we discuss, where adequately designed case-control studies are used, gene-disease association results would be incomparable between family-based and case-control studies only if genetic heterogeneity was present. These results do not support the presence of such genetic heterogeneity in schizophrenia. (c) 2005 Elsevier Ltd. All rights reserved.
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