期刊
PEPTIDES
卷 27, 期 10, 页码 2434-2444出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2005.12.016
关键词
neurotensin; GI tract; motility; inflammation; signaling
It is well established that interactions of neuropeptides with several cell types at various parts of the intestine are critically involved in intestinal pathophysiology. Among them, neurotensin has been identified as an important mediator in the development and progress of several gastrointestinal functions and disease conditions, exerting its effects by interacting with specific receptors that exert direct and indirect effects on nerves, epithelial cells, and cells of the immune and inflammatory systems. This review summarizes our recent understanding on the participation of neurotensin in the physiology and pathophysiology of the small and large intestine, and discusses various mechanisms that could be involved in these actions. (c) 2006 Elsevier Inc. All rights reserved.
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