期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 1, 期 4, 页码 586-597出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200600100
关键词
allylation; asymmetric synthesis; Grignard reagents; organocopper reagents; stereoselectivity
This study introduces the ortho-diphenylphosphanylbenzoate (o-DPPB)/o-DPPB oxide system as a switchable directing/nondirecting leaving group in a copper-mediated allylic substitution with Grignard and organozinc reagents. With this system, the regioselective, stereospecific, and stereodivergent construction of quaternary as well as tertiary carbon centers is possible in a reliable and predictable fashion. Starting from one substrate enantiomer, both optical antipodes of the substitution products are readily available. Hence, this methodology features reversed polarity in comparison to established enolate alkylation chemistry and may be an interesting alternative, particularly for the construction of quaternary stereogenic carbon centers.
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