期刊
JOURNAL OF IMMUNOLOGY
卷 177, 期 7, 页码 4927-4932出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.7.4927
关键词
-
类别
ICOS is expressed on activated T cells and particularly on CXCR5(+) follicular Th cells in germinal centers (GC). Its deletion leads to a profound deficiency in memory B cell formation and switched Ab response in humans. Here, we show that in ICOS-deficient patients the generation of GCs is severely disturbed, and the numbers of circulating CXCR5(+)CD45RO(+) memory CD4 T cells are significantly reduced, indicating an essential role of ICOS in the differentiation of CXCR5(+)CD4 T cells. The GC-specific CD57(+)CXCR5(+) subpopulation is virtually absent. In ICOS-/- mice, the decrease of circulating CXCR5(+)CD4 T cells reflects the reduction of CXCR5' follicular Th cells in lymph nodes and spleen. Therefore, in concurrence with the absence of CXCR5' T cells in the blood of CD40L-deficient patients, these data support the hypothesis that circulating CD57(+)CXCR5(+) T cells are GC derived and thus may serve as a surrogate marker for the presence of functional GCs in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据