期刊
BEHAVIOURAL BRAIN RESEARCH
卷 173, 期 1, 页码 148-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2006.06.008
关键词
conditioned cues; drug seeking; food reward; metabotropic glutamate receptors; relapse
资金
- Intramural NIH HHS Funding Source: Medline
We recently reported that systemic injections of the mGluR(2/3) agonist LY379268, which decreases evoked glutamate release, attenuate context-and discrete cue-induced reinstatement of heroin seeking, but not heroin self-administration. Here, we report that systemic injections of LY379268 attenuate context- and discrete cue-induced reinstatement of sucrose seeking, but not sucrose self-administration. These results suggest that similar neuronal mechanisms mediate cue-induced relapse to opiate- and palatable food seeking. Published by Elsevier B.V.
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