期刊
AIDS
卷 20, 期 15, 页码 1984-1986出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.aids.0000247124.35129.e1
关键词
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The cytosine deaminase APOBEC3G has been identified as a host factor that inhibits HIV-1 replication. We investigated whether genetic variants of APOBEC3G that could potentially affect the protein's expression or function were associated with the risk of infection in 122 Caucasians highly exposed to HIV-1. A novel C40693T variant was significantly associated with an increased risk of infection, suggesting that there might be a role for APOBEC3G in susceptibility to HIV-1 infection that warrants further investigation.
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