期刊
NEURON
卷 52, 期 1, 页码 15-31出版社
CELL PRESS
DOI: 10.1016/j.neuron.2006.09.001
关键词
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资金
- NIA NIH HHS [R01 AG023611, P50 AG08702, P01 AG010491, R01 AG025161, P01 AG010491-14, P50 AG008702, P01 AG10491] Funding Source: Medline
- NINDS NIH HHS [R01 NS41017, R01 NS041017] Funding Source: Medline
During the first 100 years of Alzheimer's disease research, this devastating and intractable disorder has been characterized at the clinical, histological, and molecular levels. Nevertheless, many key mechanistic questions remain unanswered. Here we will emphasize the importance of the cell biology of Alzheimer's disease, reviewing the relevant literature that has expanded our mechanistic understanding, with a particular focus on pathways regulating protein sorting. Accumulated evidence indicates that sorting pathways may be uniquely vulnerable to disease pathogenesis, and recent studies have begun to reveal disease-related defects in the regulation of protein sorting.
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