期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 348, 期 4, 页码 1261-1271出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2006.07.198
关键词
transcription; RNA polymerase I; RNA polymerase II; DNA binding; bioinformatics; orthologous promoters; computational biology; chromatin immunoprecipitation; pathway analysis
资金
- NHGRI NIH HHS [T32-HG00046, T32 HG000046] Funding Source: Medline
- NIA NIH HHS [R01 AG014456, AG14456] Funding Source: Medline
Basonuclin (Bnc 1) is a transcription factor that has an unusual ability to interact with promoters of both RNA polymerases I and II. The action of basonuclin is mediated through three pairs of evolutionarily conserved zinc fingers, which produce three DNase I footprints on the promoters of rDNA and the basonuclin gene. Using these DNase footprints, we built a computational model for the basonuclin DNA-binding module, which was used to identify in silico potential RNA polymerase II target genes in the human and mouse promoter databases. The target genes of basonuclin show that it regulates the expression of proteins involved in chromatin structure, transcription/DNA-binding, ion-channels, adhesion/cell-cell junction, signal transduction, and intracellular transport. Our results suggest that basonuclin, like MYC, may coordinate transcriptional activities among the three RNA polymerases. But basonuclin regulates a distinctive set of pathways, which differ from that regulated by MYC. (c) 2006 Elsevier Inc. All rights reserved.
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